CLEMSON, S.C. -- Chris Blewitt made a 48-yard field goal with six seconds left as Pittsburgh stunned No. 3 Clemson 43-42, spoiling a record-setting Saturday for quarterback Deshaun Watson and complicating the Tigers path back to the College Football Playoff.It was the biggest win for the Panthers (6-4, 3-3 Atlantic Coast Conference) since knocking off No. 2 West Virginia 13-9 in 2007.Watson threw for an ACC record 580 yards and three touchdowns for Clemson (9-1, 6-1). But his third interception gave Pitt the chance to crawl back from a 42-34 deficit. After Saleem Brightwells pick and 70-yard return, James Conner finished the drive with a 20-yard TD run.The Panther defense, which gave up 630 yards, rose up when it counted and stopped Wayne Gallman short on third and fourth down to take the ball with 58 seconds left. Two passes to Scott Orndoff put Pitt within range and Blewitt nailed the kick to send the Panthers into a frenzy.Nathan Peterman had a career-best five TD passes and 308 yards. Conner rushed for 132 yards and a touchdown. He also caught one of Petermans scoring throws.Clemson had its offense going. Gallman ran for three TDs and Mike Williams had 15 catches for 202 yards and a touchdown.It was Clemsons first loss at home since 2013 when Florida State, the eventual national champions, won 51-14. It was also the Tigers first regular-season loss since November 2014 at Georgia Tech, a run of 23 straight games.THE TAKEAWAYPittsburgh: The Panthers showed that coach Pat Narduzzis program is taking hold. Peterman stayed calm in the face of Clemsons strong pass rush and Conner was able to avoid the Tigers middle duo of Carlos Watkins and Dexter Lawrance to keep Pitt moving.Clemson: Many non-Tiger fans will say this team had it coming after escaping with close wins at home against No. 5 Louisville (42-36 on Oct. 1) and North Carolina State (24-17 in overtime on Oct. 15) after the Wolfpack missed the potential game-winning kick to end regulation. Clemsons path is still clear -- win out and hope its one-loss season is better than most others.UP NEXTPittsburgh closes the year with two games at home, starting with Duke next week.Clemson will try to earn the ACC Atlantic Division title with a win at Wake Forest next Saturday.---More AP college football: www.collegefootball.ap.orgCustom Philadelphia Eagles Jerseys . "It was nerve-wracking, but we pulled through," said Collaros, who threw four touchdown passes to lead the Toronto Argonauts (8-4) to a 33-27 win over the Calgary Stampeders (9-3) in front of 28,781 fans at McMahon Stadium. Custom Oakland Raiders Jerseys . LOUIS -- Mike Smith is used to facing plenty of shots, so this was nothing new. http://www.footballcustomjerseys.com/custom-chicago-bears-jerseys-108c.html . Isner, ranked No. 14, won his eighth career singles title and took the title in New Zealand for the second time after his victory in 2010. The match was similar to Isners quarterfinal victory over fifth-seeded Philipp Kohlschreiber which went to three sets, all tiebreaks and contained no breaks of serve. Custom Baltimore Ravens Jerseys . Newcastle dominated in the early stages but City weathered the storm and then raised its game in extra time. Negredo broke the deadlock from close range after a simple move in the 99th minute before Dzeko took the ball round goalkeeper Tim Krul to seal the victory in the 105th. Custom Cleveland Browns Jerseys .J. -- Pitcher Carl Pavano is retiring after 14 major league seasons. GLENDALE, Ariz. -- The Arizona Coyotes assigned 2015 first-round pick Dylan Strome to the Erie Otters of the junior Ontario Hockey League on Sunday.The 19-year-old Strome had an assist and averaged 13:41 of ice time in seven games with the Coyotes this season. He was drafted third overall.Dylan has made exceptional progress and continues to make strides to being an elite center in this league, Coyotes general manager John Chayka said. At this ppoint in time we felt it was best for his development to get him back playing in junior, but his future in the NHL is very bright.ddddddddddddBecause Strome still has junior eligibility, he isnt allowed to play in the Coyotes farm system.Last season, he had 37 goals and 74 assists in 56 regular-season games for Erie. ' ' '