SANTA CLARA, Calif. -- The previous time the 49ers traveled to play quarterback Matt Ryan in Atlanta, the stakes were high.It was the NFC championship game in January 2013, when Ryan and the top-seeded Falcons were looking to make their second Super Bowl appearance in franchise history.Ryan was having the best season of his career, but ran into San Franciscos defense.The 49ers rallied for a 28-24 victory, culminated by a fourth-down pass break-up from NaVorro Bowman with 1:13 remaining, sending Jim Harbaughs team to the Super Bowl.It was going good for us, we were rolling, said cornerback Tramaine Brock, one of San Franciscos eight remaining players that played in that game. Champagne shower in the locker room.Fast forward nearly four years and the Falcons offense again looks championship-caliber, only Ryan is having an even better season.Hes having a MVP-type season quarterbacking the leagues highest-scoring offense. His 113.2 passer rating is far better than his previous career high of 99.1 from that 2012 season.San Francisco (1-12), meanwhile, is looking to end its franchise-worst losing streak at 12. There wont be any champagne flowing in the locker room while the 49ers try to avoid finishing with fewer than two wins for the first time in history.Ryan says hes benefiting from being in the second season of coordinator Kyle Shanahans offense.49ers coach Chip Kelly said it doesnt matter what offense Ryans running.Matts one of those quarterbacks that transcends any system, he said. Hes had a couple different coordinators and been successful with whoever was coaching him. Thats just the type of player he is. I think hes an elite quarterback.Ryan ranks second in passer rating, second in yards (4,050), tied for second in touchdown passes (30) and fourth in completion rate (68.3 percent).I think everybodys a little bit more comfortable, year two in the system, and understands just the ins and outs and the nuances of the system a little bit better, Ryan said during a conference call. I think were more comfortable and I think weve got some more good players.Ryan has had new options at his disposal, including speedy receiver Taylor Gabriel and Mohamed Sanu, whos turned into a valuable partner to Julio Jones, the NFLs leader in yards receiving.But Ryan was without Jones (toe) and Sanu (groin) last week when the Falcons traveled to play the struggling Rams.It didnt matter as Ryan threw three touchdown passes in the 42-14 win. Gabriel caught a 64-yard touchdown pass, his fourth, all 25 yards or longer.I thought our guys stepped up and played really well. Its not easy when youre top two guys go down, Ryan said. I thought our guys didnt blink.Jones hasnt practiced this week and is uncertain to play Sunday against the 49ers last-ranked defense. Sanu has been limited.The 49ers will likely be without receiver Torrey Smith, who sustained a concussion when he slammed his head into the turf on an incompletion in the third quarter of the overtime loss to the Jets.Smith lost consciousness, he said, and has a gap in his memory spanning from when the play was called to his drive home after the game.Hes been in the concussion protocol this week and has yet to return to practice, but says hes improving.I dont remember anything. So, thats just one of the things that comes with it, Smith said. But as long as Im feeling better, each and every day, thats all Im going to concentrate on right now.---For more NFL coverage: www.pro32.ap.org and http://twitter.com/AP-NFLErik Gonzalez Jersey .875,000, avoiding arbitration. 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Grant Jackson Jersey . The Cincinnati Reds remain perfect with their speedy rookie outfielder in the starting lineup.ESPN NFL Insider Mike Sando spends each Sunday with ESPN NFL analyst Jon Gruden and the Monday Night Football crew. This week, theyre in Chicago, for the Minnesota Vikings-Chicago Bears matchup (ESPN, 8:30 p.m. ET). Here are some takeaways from Gruden on the game.CHICAGO -- The Vikings look vulnerable despite taking an NFC North-leading 5-1 record into their Monday Night Football visit to Soldier Field. Other contending teams around the conference will be watching to see if the Bears can keep Minnesota on the ropes following the Vikings rough outing -- and their first loss of 2016 -- at Philadelphia last week.The Bears have no shortage of their own issues,, of course, but the five-point formula for beating the Vikings is worth our attention regardless.dddddddddddd1. Overwhelm the Vikings offensive lineVikings coach Mike Zimmer used the word soft to describe his offensive line following the debacle at Philly. That was really harsh. The individual players on this line are not soft, but they have undoubtedly been vulnerable. The Eagles overwhelmed the Vikings with perimeter blitzes. They got home with free safety blitzes, strong safety blitzes, nickel corner blitzes -- you name it. ' ' '